Event Analysis
Interim analysis of all events in the first 6.5 years after the start of the study
Within the GCKD study, all cardiovasular and renal outcomes as well as all hospitalizations of the study patients are continuously recorded. The evaluation and adjudication of the pseudonymized endpoints is performed continuously by a small team of dedicated physicans. This ensures uniform coding.
The comprehensive adjudication catalogue focuses on occurrence of events, and comprises eight main event groups: cardiovascular (“A”), cerebrovascular (“B”), peripheral vascular (“C”), microangiopathy in diabetes (“D”), renal (“E”), death (“F”), cancer (“G”), and hospitalization due to infection (“H”). Within these categories, events are further classified into subcategories with up to five levels, allowing to specify the event as detailed as possible
As part of CKD-Napp, a substudy of GCKD, interactive plots were generated with R-shiny/Shiny Proxy based on all events achieved in the 6.5 years after inclusion and made available via an R-Shiny web application.
![Link to the event pages](https://www.gckd.org/files/2024/05/Rshiny-Plot-300x144.png)
Steinbrenner I, Kotsis F, Kosch R, Meiselbach H, Bärthlein B, Stockmann H, Lipovsek J, Zacharias HU, Altenbuchinger M, Dienemann T, Wytopil M, Bächle H, Sommerer C, Titze S, Weigel A, Weissensteiner H, Schönherr S, Forer L, Kurz NS, Menne J, Schlieper G, Schneider MP, Schäffner E, Kielstein JT, Sitter T, Floege J, Wanner C, Kronenberg F, Köttgen A, Busch M, Krane V, Schmid M, Eckardt KU, Schultheiss UT. Interactive exploration of adverse events and multimorbidity in CKD. Nephrol Dial Transplant. 2024 Apr 25